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In a joint study with the University of Arizona by researchers from Stony Brook University Hospital and Wake Forest School of Medicine in the USA, blood samples taken from two Covid-19 patients were examined.
Researchers noticed the enzyme sPLA2-11A circulating in the blood. It is stated that this enzyme may be a method of great importance for predicting the death of patients from Covid-19.
Dr Floyd (Ski) Chilton, one of the senior authors of the study published in the Journal of Clinical Investigation, likens the situation to a bell curve and points out that as resistance to the disease rises, it turns into tolerance to the virus.
Chilton explains, “This enzyme tries to kill the virus, but after a point it is released in such a large amount that things start to go bad, destroying the patient’s membrane cells. And that’s how it causes organ failure and death.”
BLOOD VALUES DEFINED
One of the co-authors of the study, Prof. Maurizio Del Poeta says the research began analyzing lipids and metabolites in blood samples from patients after Dr Chilton identified factors that could contribute to the course of the disease.
The research team reviews data from thousands of patients and traditionally focuses on patients’ lipid and metabolite values alongside risk factors such as age, body mass index and pre-existing conditions.
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Assistant Professor of the University of Arizona, Dr. Justin Snider states that with this study, they found a similarity in the metabolites of patients who succumbed to the disease, and notes that the resulting metabolites reveal an energy disorder in the cell and an unexpectedly high dose of sPLA2-11A enzyme.
In the analysis, this enzyme rate is about half a nanogram per milliliter in a healthy person, while this rate is above 10 nanograms in 63 percent of severe Covid-19 patients. Researchers point out that the rate of enzymes is very high, especially in those who lost their lives due to Covid-19.
“DETACHING ENZYME’ IS VERY LIKELY TO THE ENZYME IN RAPITAL VESSEL”
According to researchers from Wake Forest School of Medicine, the enzyme they call “degrading” has an effect that is common in severe inflammation such as sepsis or in conditions such as hemorrhagic and cardiogenic shock.
Previous research has revealed that the enzyme is genetically very similar to an essential enzyme in rattlesnake venom.
Scientists are conducting research on whether this enzyme also leads to the long Covid-19.